Introduction

Celosia argentea (C. Argentea) is a plant found in tropical and subtropical regions with ornamental and agricultural applications (“Celosia Argentea”). However, its potential medicinal properties, notably its anti-inflammatory properties, have not been thoroughly investigated. The purpose of this project is to investigate the anti-inflammatory properties of C. Argentea extracts both invitro and in-vivo.

Inflammation is a complex biological reaction that protects the body from infection while also facilitating healing after tissue injury. Toxic substances, bacteria, damaged cells, and accumulating exudates can trigger a cascade of reactions (Chen et al.) While inflammation is an important aspect of the immune system’s protective systems, uncontrolled or chronic forms of diseases can be dangerous and are linked to a variety of disorders. To prevent chronic diseases, including obesity, diabetes, Alzheimer, or even cancer, which are frequently associated with irregularities in the homeostatic processes of humans, anti-inflammation studies can contribute to the pathogenesis of many modern chronic diseases (Chen et al.). Persistent inflammation produced by tissue malfunction might result in the ongoing release of macrophages, worsening the inflammatory response. Given this consequence of jeopardizing public health and quality of life, the necessity of anti-inflammatory properties is significant.

Experiment

Ethanol and ethyl extracts of C. Argentea are produced and tested for their effects on biological indicators of inflammation. The methodology consists of a series of laboratory procedures, such as extraction, treatment, and spectrophotometric measurement. 

12 experiment tubes were prepared and divided with purposes of negative control, positive control, tests tubes and control tubes for each concentration. Then necessary materials required for each part into added to the tubes utilizing a micropipette with a range of 100 μL to 1000 μL in a total volume of 4000 μL.

Result

The result suggests that there was substantial negative association between extract concentration and percentage suppression of the inflammatory response. The equation's negative slope (-0.0187-0.0187) indicates that as the concentration of C. Argentea extract increases, the inhibition percentage drops. This unexpected finding shows that larger quantities of the extract may impair its efficacy in reducing inflammation in vitro.

Additional in-vivo investigations were carried out to assess the antiinflammatory activity of C. Argentea extracts. These investigations explored providing different amounts of the extract to animal models with generated inflammatory states. The results followed a consistent pattern with the in-vitro findings, with intermediate quantities of the extract providing considerable anti-inflammatory benefits and greater amounts being less beneficial.

The inverse association established between extract concentration and inhibition % calls for further exploration into the pharmacodynamics and pharmacokinetics of the active chemicals included in the extract. Understanding these pathways is critical for improving the formulation and delivery of C. Argentea as a possible therapeutic agent for inflammatory diseases. Future research should focus on isolating and characterizing C. Argentea's active ingredients in order to determine the precise chemicals responsible for its anti-inflammatory properties. Furthermore, studying the synergistic and antagonistic interactions of these drugs at different dosages can offer useful information for creating more effective antiinflammatory medicines. Finally, clinical studies will be required to convert these preclinical discoveries into possible therapeutic uses for humans with inflammatory disorders.

Conclusion

In conclusion, Celosia Argentea possesses anti-inflammatory qualities because it inhibits absorption. For further research, the plant can be extracted by fractionation and purification. This would allow for a more accurate outcome in terms of value and correlation.